What Is Postural Orthostatic Tachycardia Syndrome (POTS)? Postural Orthostatic Tachycardia Syndrome (POTS) affects between 1 and 3 million Americans, typically women between 15 and 50 years old. It is a dysfunction of the autonomic nervous system, or a dysautonomia disorder, which involves blood pressure, heart rate, digestion, urination, breathing, and body temperature. As the Standing Up…